A failed IVF cycle is deeply disappointing. It is also common: many couples need more than one cycle. Understanding why a cycle may not have worked, and what can be changed, helps you decide on the next step.
How common is IVF failure?
Even when everything looks good, not every embryo implants. The chance of success per cycle depends mainly on the woman’s age, egg and sperm quality and the embryos available. Many couples conceive in a later cycle.
Common reasons IVF fails
Egg quality
Egg quality, closely linked to age, is the most common reason embryos do not develop or implant. See age and fertility.
Low ovarian reserve
Fewer eggs mean fewer embryos to choose from. See low AMH and IVF.
Sperm quality
Poor sperm quality can affect fertilisation and embryo development. ICSI may help.
Embryo chromosomal problems
Many embryos that fail to implant, or miscarry, have chromosomal abnormalities, especially as age increases. See preimplantation genetic testing.
The uterus
Polyps, fibroids, scarring, a thin lining or infection can affect implantation. See how uterine conditions affect fertility.
Other factors
Hydrosalpinx (fluid-filled tubes), thyroid disease, poorly controlled diabetes, smoking and excess weight can also lower the chances.
What happens after a failed cycle?
A review consultation looks at how you responded to stimulation, egg and embryo numbers and quality, and the transfer itself. Your doctor may suggest:
- Changes to the stimulation protocol
- Tests of the uterus such as hysteroscopy
- Treating conditions such as hydrosalpinx or thyroid problems
- ICSI, blastocyst culture or genetic testing of embryos in selected cases
- Discussing donor eggs or sperm when appropriate
Read more in what to do when IVF keeps failing.
Looking after yourself
Give yourself time to grieve. Talk to your partner, family or a counsellor. Many couples find it helps to wait until they feel ready before planning another cycle. See coping with the emotional impact.
Frequently asked questions
Why did my IVF fail with good embryos?
Even good-looking embryos may have chromosomal problems that cannot be seen under the microscope. Uterine factors and chance also play a part.
How long should I wait before another IVF cycle?
Many women can start again after one or two menstrual cycles, but it is important to feel emotionally ready. Your doctor will advise.
How many IVF cycles should we try?
There is no fixed number. Your doctor will discuss your chances based on your age and the results of previous cycles.
If you have questions about your own situation, you can meet our doctors at our Basavanagudi, Koramangala and Ballari centres, or contact us to book an appointment.
This article is for general information and does not replace medical advice. Treatment decisions should be made with a qualified doctor who knows your history.