To reduce the risk of transmission, HIV–positive men can use condoms and their partner can take antiretroviral medication prior to treatment. Furthermore, the laboratory and clinical staff handling the IVF process must adhere to strict safety protocols to avoid transmission. A comprehensive HIV screening process should also be carried out prior to treatment. Lastly, it is essential to use assisted reproductive technologies that eliminate contact with semen, such as in vitro maturation or intracytoplasmic sperm injection.