When IVF does not work more than once, it can feel as though you have run out of options. Repeated failure is difficult, but a careful review often points to changes that can help, and there are other paths to parenthood to consider.
What is repeated implantation failure?
Repeated implantation failure usually describes not becoming pregnant after several transfers of good-quality embryos. Doctors use slightly different definitions, but the aim is the same: to look again at every step of treatment.
Coping with IVF disappointment
It is normal to feel grief, anger or exhaustion. Give yourselves time before making decisions, and lean on each other, family, friends or a counsellor. See coping with the emotional impact of infertility.
Looking for a cause
Embryo factors
Chromosomal problems in embryos are the most common reason good-looking embryos do not implant, especially with increasing age. Genetic testing of embryos may be discussed. See preimplantation genetic testing.
Uterine factors
Polyps, fibroids, a septum, scarring or chronic inflammation of the lining can affect implantation. A hysteroscopy can examine the uterine cavity.
Fallopian tubes
Fluid-filled tubes (hydrosalpinx) can lower IVF success, and treating them before another transfer can help.
General health
Thyroid disease, diabetes, blood-clotting disorders, smoking and weight can all play a part.
Sperm factors
Sperm DNA quality and other sperm factors may be assessed in some cases. See semen analysis.
Next steps
Depending on the findings, options may include:
- A change in stimulation protocol or laboratory techniques
- Treating uterine or tubal problems before the next transfer
- Frozen embryo transfer in a carefully prepared cycle
- Using donor eggs, donor sperm or donor embryos
- Surrogacy, within the rules of Indian law
- Deciding to stop treatment, which is also a valid choice
Read more in failed IVF: a reality for many women.
Getting a second opinion
A fresh review by another specialist can sometimes offer a new perspective. Bring all your records, including stimulation details, embryo reports and test results.
Frequently asked questions
How many failed IVF cycles is considered repeated failure?
Definitions vary, but it usually refers to not achieving a pregnancy after several transfers of good-quality embryos.
Can a hysteroscopy help after failed IVF?
It can find and treat problems such as polyps or scarring in the uterus that may affect implantation.
Should we try donor eggs after failed IVF?
Donor eggs may be an option when egg quality is likely to be the main problem. It is a personal decision, and counselling is part of the process.
If you have questions about your own situation, you can meet our doctors at our Basavanagudi, Koramangala and Ballari centres, or contact us to book an appointment.
This article is for general information and does not replace medical advice. Treatment decisions should be made with a qualified doctor who knows your history.